Did you know?

The IWMF raised more than five million dollars for WM medical research

Did you know?

The IWMF raised more than 60 support groups in North America and nearly 20 others world-wide

Did you know?

The IWMF has a current worldwide membership of nearly 4,000

Did you know?

IWMF-TALK is a wonderful place to share information and learn from other survivors

Did you know?

Each year 1,500 new cases of Waldenstrom's macroglobulinemia are diagnosed in the USA

Did you know?

Volunteers at the IWMF Telephone Lifeline are waiting to share their experiences with you

Did you know?

You can order DVD recordings of past WM Educational Forums online or by mail

Did you know?

All IWMF programs and services are funded by WM survivors, caregivers, friends, and family

Revised REAL Lymphoma classifications

Revised REAL Lymphoma Classifications:


Waldenstroms is now included with "Lymphoplasmacytic Lymphoma".

Updated REAL/WHO Classification

B-cell neoplasms

I. Precursor B-cell neoplasm: precursor B-acute lymphoblastic

leukemia/lymphoblastic lymphoma (B-ALL, LBL)

II. Peripheral B-cell neoplasms

A. B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma

B. B-cell prolymphocytic leukemia

C. Lymphoplasmacytic lymphoma (incl. WM)/immunocytoma

D. Mantle cell lymphoma

E. Follicular lymphoma

F. Extranodal marginal zone B-cell lymphoma of MALT type

G. Nodal marginal zone B-cell lymphoma (+/- monocytoid B-cells)

H. Splenic marginal zone lymphoma (+/- villous lymphocytes)

I. Hairy cell leukemia

J. Plasmacytoma/plasma cell myeloma

K. Diffuse large B-cell lymphoma

L. Burkitt's lymphoma

T-cell and putative NK-cell neoplasms

I. Precursor T-cell neoplasm: precursor T-acute lymphoblastic

leukemia/lymphoblastic lymphoma (T-ALL, LBL)

II. Peripheral T-cell and NK-cell neoplasms

A. T-cell chronic lymphocytic leukemia/prolymphocytic leukemia

B. T-cell granular lymphocytic leukemia

C. Mycosis fungoides/Sezary's syndrome

D. Peripheral T-cell lymphoma, not otherwise characterized

E. Hepatosplenic gamma/delta T-cell lymphoma

F. Subcutaneous panniculitis-like T-cell lymphoma

G. Angioimmunoblastic T-cell lymphoma

H. Extranodal T-/NK-cell lymphoma, nasal type

I. Enteropathy-type intestinal T-cell lymphoma

J. Adult T-cell lymphoma/leukemia (HTLV 1+)

K. Anaplastic large cell lymphoma, primary systemic type

L. Anaplastic large cell lymphoma, primary cutaneous type

M. Aggressive NK-cell leukemia

Hodgkin's lymphoma (Hodgkin's disease)

I. Nodular lymphocyte-predominant Hodgkin's lymphoma

II. Classical Hodgkin's lymphoma

A. Nodular sclerosis Hodgkin's lymphoma

B. Lymphocyte-rich classical Hodgkin's lymphoma

C. Mixed cellularity Hodgkin's lymphoma

D. Lymphocyte depletion Hodgkin's lymphoma