Revised REAL Lymphoma classifications

Revised REAL Lymphoma Classifications:

 

Waldenstroms is now included with "Lymphoplasmacytic Lymphoma".

Updated REAL/WHO Classification

B-cell neoplasms

I. Precursor B-cell neoplasm: precursor B-acute lymphoblastic

leukemia/lymphoblastic lymphoma (B-ALL, LBL)

II. Peripheral B-cell neoplasms

A. B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma

B. B-cell prolymphocytic leukemia

C. Lymphoplasmacytic lymphoma (incl. WM)/immunocytoma

D. Mantle cell lymphoma

E. Follicular lymphoma

F. Extranodal marginal zone B-cell lymphoma of MALT type

G. Nodal marginal zone B-cell lymphoma (+/- monocytoid B-cells)

H. Splenic marginal zone lymphoma (+/- villous lymphocytes)

I. Hairy cell leukemia

J. Plasmacytoma/plasma cell myeloma

K. Diffuse large B-cell lymphoma

L. Burkitt's lymphoma

T-cell and putative NK-cell neoplasms

I. Precursor T-cell neoplasm: precursor T-acute lymphoblastic

leukemia/lymphoblastic lymphoma (T-ALL, LBL)

II. Peripheral T-cell and NK-cell neoplasms

A. T-cell chronic lymphocytic leukemia/prolymphocytic leukemia

B. T-cell granular lymphocytic leukemia

C. Mycosis fungoides/Sezary's syndrome

D. Peripheral T-cell lymphoma, not otherwise characterized

E. Hepatosplenic gamma/delta T-cell lymphoma

F. Subcutaneous panniculitis-like T-cell lymphoma

G. Angioimmunoblastic T-cell lymphoma

H. Extranodal T-/NK-cell lymphoma, nasal type

I. Enteropathy-type intestinal T-cell lymphoma

J. Adult T-cell lymphoma/leukemia (HTLV 1+)

K. Anaplastic large cell lymphoma, primary systemic type

L. Anaplastic large cell lymphoma, primary cutaneous type

M. Aggressive NK-cell leukemia

Hodgkin's lymphoma (Hodgkin's disease)

I. Nodular lymphocyte-predominant Hodgkin's lymphoma

II. Classical Hodgkin's lymphoma

A. Nodular sclerosis Hodgkin's lymphoma

B. Lymphocyte-rich classical Hodgkin's lymphoma

C. Mixed cellularity Hodgkin's lymphoma

D. Lymphocyte depletion Hodgkin's lymphoma