 |
Compiled by the NHLlow electronic group,
the largest cancer eGroup on the planet for a few years now. Last
updated: April 14, 2001 For more info on the NHLlow eGroup mailing
list, includingall past posts and how to (Un)subscribe NHLlow visit
(see info):
NHLlow Archives are here: http://www.egroups.com/group/nhllow/
Or please search Medline for
the latest information on various Protocols: http://www.ncbi.nlm.nih.gov/PubMed/
Key: N - Number of Patients in
Study with low grade lymphoma Nx - Number of patients in study with
Low/Intermediate/High grade Lymphoma (can't differentiate low grade/indolent
cases) CR - Complete Remission PR - Partial Remission TR - Total
Response (CR+PR) Given if CR and PR are unclear PFS - progression-free
survival OS - Overall survival * - denotes recently added/updated
- all info in NHLlow archives (Note the new section on searching
for Clinical Trials at the bottom of this.) ===================================
LIST OF PROTOCOLS: Various sections ===================================
SECTION I: MONOCLONAL ANTIBODIES (Immunotherapy)
a) COLD/UNLABELED/NAKED: Approved:
Rituxan (aka: Rituximab, IDEC-C2B8)N-151,CR-6%,PR-44% (Rituxan/IDEC-Y2B8
consolidation http://www.egroups.com/group/nhllow/1141.html
) Trials: CAMPATH1H (aka: CD-52) (notes: harsh toxicity)
Rituxan+Cyclophosamide+Doxorubicin+Vincristine+Prednisone Rituxan+Interleukin-2
Rituxan (as maintenance therapy after Fludarabine) Rituxan +
CHOP N-35,CR-63%,PR-37% : TR-100% Rituxan+MGBG(Mitoguaxone)
Dexamethasone+Rituxan Nipent+Rituxan b) HOT/LABELED/RADIOLABELED/RADIOIMMUNOTHERAPY:
Bexxar (aka: Anti-B1)N-45,CR-31%,PR-29% : note- CR-71% as first-line
(Bexxar Consolidation post: other name (Tositumomab) http://www.egroups.com/list/nhllow/1140.html
) ZEVALIN (aka Ibritumomab, IDEC-Y2B8) Oncolym(Lym-1,131I-Lym-1
,67Cu-2IT-BAT-LYM-1) Epratuzumab (aka LymphoCide) (CD22 - LL2
antibody) Bexxar+CHEMO Bexxar + CVP Bexxar/IDEC-Y2B8 + Interleukin-2
BetaLT (formerly BETATHINE)
SECTION II: CANCER VACCINES (Immunotherapy
specific to low grade lymphoma):
Vaxid (Vical) N-8,CR-25%,PR-12.5%
Vaccine (Genzyme Transgenics) Cancer Vaccine: MGV (Progenics)
Vaccine from Antigenics British Vaccine (Freda Stevenson remember
that name) Proleukin (aldesleukin - a recombinant form of interleukin-2
( IL-2) ) Pre-Clinical: Cancer Vaccine: Biomira's Biosource
(Levy) http://www.egroups.com/group/nhllow/1074.html IMMUNOTOXIN
TARGETED THERAPY
SECTION III: ANTIANGIOGENIC THERAPIES
Therapies that may help low grade lymphoma are: Thalidomide,
TNP-470, Troponin, Platelet Factor 4, Interferon alpha, and the
big guns, Angiostatin/Endostatin/2ME2/ possibly aaATIII. These drugs
target the human endothelial cell which a tumor needs in order to
get a blood supply and become lethal.) SECTION IV: GENE THERAPY:
Genasense (Formerly G3139 chemo
sensitizer/BCL2 antisense) G3139 + Cyclophosphamide Pre Clinical/In
their infancy (New Identified Genes specific to lymphoma)::
INXC-6295 P53 T14;18 18q21t 14q32 FcgRIIB WT1
SECTION V: BMTs
Allogeneic Bone Marrow Transplant
Autologous BMT Autologous + Gene therapy Autologous + IL2 Stem
Cell Transplant Cord Blood Transplant Stem Cell Transplant +
Bexxar Syke's 'mixed chimerism' Bexxar+ABMT BEAM+autologous
stem cell transplantation
SECTION VI: CHEMOTHERAPY/OTHER NOT YET
CATEGORIZED:
Approved:
CHOP CVP COP Fludarabine (aka
FAMP,Fludara) Results vary by cell type see below Leukeran
(Cholorambucil) Lustatin (aka: Cladribine, 2-chlorodeoxyadenosine,
2CdA) ProMACE-CytaBOM N-39,CR-56%,PR-39% Dolastatin Arsenic
Trioxide FLT3 Ligand (CD40)
Other (phases unknown/work in progress
to categorize): Pentostatin (aka:dCF) TR-17% Taxol (Paclitaxel)
Nx-96, CR-10%,PR-15% Paclitaxel + Quinine (adding quinine to
paclitaxel has limited benefit) BTK (Chemo sensitizer) http://www.egroups.com/group/nhllow/1071.html
Cytoxin (cyclophosphamide) NOVANTRONE (Mitoxantrone) Fludarabine
+ Mitoxantrone Fludarabine + Paclitaxel N-19, CR-11.5%, PR-42%
Fludarabine + Cytoxin Fludarabine + Cladribine Fludarabine +
CAMPATH1H Fludarabine + Octreotide Fludarabine + Interferon
alfa-2b N-29 TR-28% FND(Fludarabine + Mitoxantrone + Dexamethasone)
N-51,CR-47%,PR-47% FMP(Fludarabine + Mitoxantrone + Prednisone)
N-48,CR-35%,PR-48% FLU-ID(Fludarabine + Idarubicin) N-10,CR-20%,PR-50%
Alternating FAMP and IFN-A FLIDA (Fludarabine + Idarubicin +
Prednisone) N-16,CR-44%,PR-50% Fludarabine + CNOP Fludaraine+Cyclophosphamide+Filgrastim
Trofosfamide Nx-37 (27 LG,7 HG, 3 HD),CR-8%, PR-41% MIZE(Ifosfamide-mesna
+ Idarubicin + Etoposide) N-54,CR-46%,PR-26% ONCASPAR PmitCEBO
Nx-20,TR-75% NOVOMAb-G2 scFv Bryostatin Intron-A(recombinant
human interferon, interferon alfa-2b) Iodine 131 Topotecan Daily
Oral Etoposide Ifosfamide/Mercaptoethane Sulfonate Yttrium Y
90 Labeled Humanized Anti-Tac MoAb & Pentetic Acid Calcium
DaunoXome(Daunorubicin) Homoharringtonine Di-dgA-RFB4 Docetaxel(Taxotere)
O6-Benzylguanine + Carmustine Cytoxin(cyclophosphamide) + Granulocyte
colony stimulating (G-CSF) 2-5A antisense compound NFL(5-fluorouracil
+ Leucovorin) DAB[389]IL-2 Idarubicin Idarubicin + Etoposide
High-dose chemo w/Carboplatin + Etoposide + Ifosfamide + ABMT
Flavopiridol Gemcitabine (Gemzar) ANTRAGEN 2-Methoxyestradiol
Pretarget(TM) + BMT Doxorubicin With Interferon Alfa-2b Doxorubicin
Without Interferon Alfa-2b PmM (prednimustine+mitoxantrone)
(CR-35%,PR-50%) WF10 Dantrolene + Azumolene EPOCH ONCO TCS Micrologix
Peptides ISIS 3521/CGP64128A DIZE Arglabin topoisomerase-I Oncophage
GTI-2040 MCP - Mitoxantrone + Chlorambucil + Prednisone CHVP
- Cyclophosphamide + Doxorubicin + Teniposide + Prednisone (N-119,
see below) CHVP - Cyclophosphamide + Doxorubicin + Teniposide
+ Prednisone + IFN (N-123, with IFN study show significant PFS
and OS compared to above) Cytarabine + Mitoxantrone N-16,CR-31%,PR-12%
(Too toxic though!) BUCY - Busulfan + Cyclophosphamide + PBSC
BEAC - Busulfan + Carmustine + Eetoposide+ Cytarabine + PBSC
BACOD-E Calcium Channel Blockers FluCyD - Fludarabine + Cyclophosphamide
+ Dexamethasone Antisense oligonucleotides (ASO's) INXC-6295
Arsenic Compounds ONTAK HumaLYM Clofarabine Allogen NeoRx's
Pretarget Ifosfamide + Etoposide Atragen IL-4 Fusion Toxin JAK3
Arglabin Smart ID10 CpG 7909 *Theralux *Nasal Interferon *Epothilone
*Troxatyl *BL22 *GD0039
POSSIBILITIES ----------------------
KRN8602 Antinuclear AutoAntibodies
(ANAs) CD40 Ligand INXC-6295 *Glivec (STI-571, need to carefully
follow this one.)
SECTION VII: PROMISING ALTERNATIVE/COMPLEMENTARY
PROTOCOLS: ----------------------------------------------------------------
(This is not the FOCUS of
NHLlow but is of NHL-info, please go there for more details: http://www.egroups.com/group/nhl-info
look for info from Karl as well as Vera.)
Green Tea Soy Based Products Naltrexone
SECTION VIII: EXPANDED INFORMATION SECTION:
Name: RITUXAN Other Names: Rituximab,
IDEC-C2B8 Overall Rating: Promising for 50% Company: IDEC Pharmaceuticals,
Inc./Genentech, Inc. Phone #(s): IDEC- (619) 550-8500
Web Page: Genentech -
www.gene.com
Name: FLUDARABINE Other Names: FLU,
Fludara, FAMP, fludarabine phosphate Overall Rating: Similar
to CHOP Company: Berlex Laboratories, Inc. Phone: Phone: 510-262-5000
Fax: 510-262-7054 Side Effects: Similar to chemotherapy. However,
alopecia and nausea/vomiting appear to be less frequent with
fludarabine. Severe neurotoxicity has been reported with fludarabine
but this is mostly in high doses. Type: antineoplastic agent
Name: BEXXAR Other Names: Anti-B1, B1 Therapy, Iodine I 131
tositumomab Company: Coulter Pharmaceutical, Inc.
New Website (01/99): http://www.coulterpharm.comCoulter
Pharmaceuticals, Inc.
Claim Bexxar will be the 'gold standard.'
Phone: (415) 842-7300, or Sylvia Wheeler (415) 842-7306 Fax:
(415) 842-7303 Address:550 California Ave, Suite 200 Palo Alto,
CA 94306 Name: VAXID Other Names: Cancer Vaccine Company: Vical
Incorporated Ticker: (NASDAQ:VICL) Phone: (619) 453-9900 Address:
9373 Towne Centre Drive -Suite 100 San Diego, CA 92121 Name:
ZEVALIN Other Names: IDEC-Y2B8 Company: IDEC Pharmaceuticals
Phone #(s): IDEC- (619) 550-8500
SECTION IX: CLINICAL TRIAL INFORMATION:
Check out: http://www.egroups.com/list/nhllow/1016.html
Or 1-800-4CANCER If you call the above
number, they use PDQ which is found at:
http://207.121.187.155/NCI_CANCER_TRIALS/zones/TrialInfo/Finding/
http://cancernet.nci.nih.gov/prot/menu/dx03432.html
(This page lists trials specific to low
grade lymphoma, stage IV)
Another really good site which
even has e-mail notification is: http://www.centerwatch.com/
or to go right to the lymphoma
specific trials by state: http://www.centerwatch.com/studies/CAT95.HTML
or http://www.uicc.org/links/#CLIN
|
|
